HIV-1: is Nef a PAK animal?
作者信息
Cullen B R
机构信息
Howard Hughes Medical Institute, Durham, North Carolina, USA.
出版信息
Curr Biol. 1996 Dec 1;6(12):1557-9. doi: 10.1016/s0960-9822(02)70770-7.
PMID:8994811
Abstract
HIV-1 Nef is clearly essential for efficient viral replication in vivo, but it has been difficult to determine why. Recent evidence that Nef specifically activates a PAK-dependent signalling cascade may be the first step in defining the mechanism of action of this enigmatic viral protein.
摘要
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