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骨骼生长：协调软骨细胞分化

Bone growth: coordinating chondrocyte differentiation.

作者信息

Wallis G A

机构信息

School of Biological Sciences, University of Manchester, UK.

出版信息

Curr Biol. 1996 Dec 1;6(12):1577-80. doi: 10.1016/s0960-9822(02)70776-8.

DOI:10.1016/s0960-9822(02)70776-8
PMID:8994817
Abstract

Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-have been found to function in a negative feedback loop that is crucial for the coordinated regulation of the rate and extent of endochondral bone growth.

摘要

已发现两种信号分子——印度刺猬因子和甲状旁腺激素相关肽——在一个负反馈回路中发挥作用，该回路对于软骨内骨生长的速率和程度的协调调节至关重要。

相似文献

1
Bone growth: coordinating chondrocyte differentiation.骨骼生长：协调软骨细胞分化
Curr Biol. 1996 Dec 1;6(12):1577-80. doi: 10.1016/s0960-9822(02)70776-8.
2
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.印度刺猬因子和甲状旁腺激素相关蛋白对软骨分化速率的调节
Science. 1996 Aug 2;273(5275):613-22. doi: 10.1126/science.273.5275.613.
3
Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation.甲状腺激素在软骨内骨形成过程中调节肥大软骨细胞分化以及甲状旁腺激素相关肽及其受体的表达。
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Putting the brakes on bone growth.抑制骨骼生长。
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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.早期发育中的甲状旁腺激素/甲状旁腺激素相关蛋白受体与印度刺猬因子调节的骨骼生长
Science. 1996 Aug 2;273(5275):663-6. doi: 10.1126/science.273.5275.663.
6
The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation.甲状旁腺激素/甲状旁腺激素相关肽受体通过直接控制软骨细胞分化来协调软骨内骨发育。
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13030-5. doi: 10.1073/pnas.95.22.13030.
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Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development.
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Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth.印度刺猬因子、甲状旁腺激素相关蛋白及其受体在大鼠出生后生长板中的表达：出生后局部作用的生长抑制反馈环的证据
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Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate.Sox5和Sox6是软骨生长板中发育和维持源细胞、柱状细胞和肥大软骨细胞所必需的。
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Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.印度刺猬因子在软骨内骨发育过程中将软骨形成与骨形成联系起来。
J Clin Invest. 2001 Feb;107(3):295-304. doi: 10.1172/JCI11706.

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