• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗原呈递细胞上的FcεRI

Fc epsilon RI on antigen-presenting cells.

作者信息

Bieber T

机构信息

Department of Dermatology, Ludwig-Maximilians University, Munich, Germany.

出版信息

Curr Opin Immunol. 1996 Dec;8(6):773-7. doi: 10.1016/s0952-7915(96)80003-3.

DOI:10.1016/s0952-7915(96)80003-3
PMID:8994854
Abstract

The high-affinity receptor for IgE, Fc epsilon RI, expressed on antigen-presenting cells such as monocytes and Langerhans' cells exhibits profound differences to its homologue expressed on mast cells and basophils. The lack of the beta chain, the presence of an intracellular pool of preformed alpha chains, highly variable surface expression, and its function (to provide antigen focusing for T cells) are some of the main issues which have led us to consider the functional role of this receptor in a new light.

摘要

在诸如单核细胞和朗格汉斯细胞等抗原呈递细胞上表达的IgE高亲和力受体FcεRI，与其在肥大细胞和嗜碱性粒细胞上表达的同源物存在显著差异。β链的缺失、预先形成的α链细胞内池的存在、高度可变的表面表达及其功能（为T细胞提供抗原聚集）是促使我们从新的角度思考该受体功能作用的一些主要问题。

相似文献

1
Fc epsilon RI on antigen-presenting cells.抗原呈递细胞上的FcεRI
Curr Opin Immunol. 1996 Dec;8(6):773-7. doi: 10.1016/s0952-7915(96)80003-3.
2
Immunoglobulin E-binding structures on antigen-presenting cells present in skin and blood.皮肤和血液中存在的抗原呈递细胞上的免疫球蛋白E结合结构。
J Invest Dermatol. 1995 May;104(5):707-10. doi: 10.1111/1523-1747.ep12606958.
3
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.表达人类高亲和力免疫球蛋白（Ig）E受体α链的转基因小鼠在肥大细胞脱颗粒和过敏反应中对人类IgE产生反应。
J Exp Med. 1996 Jan 1;183(1):49-56. doi: 10.1084/jem.183.1.49.
4
Aggregation of the high-affinity IgE receptor Fc(epsilon)RI on human monocytes and dendritic cells induces NF-kappaB activation.人单核细胞和树突状细胞上高亲和力IgE受体Fc(ε)RI的聚集可诱导NF-κB激活。
J Invest Dermatol. 2002 May;118(5):830-7. doi: 10.1046/j.1523-1747.2002.01757.x.
5
Quantification of indoleamine 2,3-dioxygenase gene induction in atopic and non-atopic monocytes after ligation of the high-affinity receptor for IgE, Fc(epsilon)RI and interferon-gamma stimulation.在IgE高亲和力受体Fc(ε)RI结扎及干扰素-γ刺激后，对特应性和非特应性单核细胞中吲哚胺2,3-双加氧酶基因诱导情况的定量分析
Clin Exp Immunol. 2003 May;132(2):247-53. doi: 10.1046/j.1365-2249.2003.02125.x.
6
Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI.FcεRIα细胞外结构域在IgE高亲和力受体FcεRI的细胞内加工和表面表达中的作用
Mol Immunol. 2008 Apr;45(8):2307-11. doi: 10.1016/j.molimm.2007.11.017. Epub 2008 Jan 7.
7
Fc epsilon ri-mediated activation of transcription factors in antigen-presenting cells.FcεRI介导抗原呈递细胞中转录因子的激活。
Int Arch Allergy Immunol. 2001 May;125(1):9-15. doi: 10.1159/000053791.
8
High-affinity immunoglobulin E receptor (Fc epsilon RI)-bearing eosinophils, mast cells, macrophages and Langerhans' cells in allergen-induced late-phase cutaneous reactions in atopic subjects.在特应性个体变应原诱导的皮肤迟发相反应中，带有高亲和力免疫球蛋白E受体（FcεRI）的嗜酸性粒细胞、肥大细胞、巨噬细胞和朗格汉斯细胞。
Immunology. 1998 Feb;93(2):281-8. doi: 10.1046/j.1365-2567.1998.00418.x.
9
Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis.FcεRI在临床未受累皮肤的朗格汉斯细胞上的表面表达与特应性皮炎、过敏性哮喘和鼻炎的疾病活动相关。
J Allergy Clin Immunol. 2003 Aug;112(2):411-9. doi: 10.1067/mai.2003.1626.
10
Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation.外周血树突状细胞表达由FcεRIα链和FcεRIγ链组成的复合物形式的FcεRI，并可利用该受体进行IgE介导的过敏原呈递。
J Immunol. 1996 Jul 15;157(2):607-16.

引用本文的文献

1
An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.人类树突状细胞中 IgE 介导的过敏原识别和呈递的研究。
BMC Immunol. 2013 Dec 13;14:54. doi: 10.1186/1471-2172-14-54.
2
Evidence for neuronal expression of functional Fc (epsilon and gamma) receptors.功能性 Fc（epsilon 和 gamma）受体的神经元表达证据。
J Allergy Clin Immunol. 2010 Mar;125(3):757-60. doi: 10.1016/j.jaci.2009.10.054. Epub 2010 Feb 4.
3
Adapters in the organization of mast cell signaling.衔接子在肥大细胞信号转导中的作用。
Immunol Rev. 2009 Nov;232(1):195-217. doi: 10.1111/j.1600-065X.2009.00834.x.
4
Quantification of indoleamine 2,3-dioxygenase gene induction in atopic and non-atopic monocytes after ligation of the high-affinity receptor for IgE, Fc(epsilon)RI and interferon-gamma stimulation.在IgE高亲和力受体Fc(ε)RI结扎及干扰素-γ刺激后，对特应性和非特应性单核细胞中吲哚胺2,3-双加氧酶基因诱导情况的定量分析
Clin Exp Immunol. 2003 May;132(2):247-53. doi: 10.1046/j.1365-2249.2003.02125.x.
5
Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors.特应性和非特应性供体树突状细胞中FcepsilonRIγ链差异表达的证据。
J Clin Invest. 2003 Apr;111(7):1047-56. doi: 10.1172/JCI15932.
6
The high-affinity IgE receptor (FcepsilonRI) blocks apoptosis in normal human monocytes.高亲和力IgE受体（FcepsilonRI）可阻止正常人单核细胞凋亡。
J Clin Invest. 2000 Jan;105(2):183-90. doi: 10.1172/JCI6895.
7
The immunoglobulin-like modules Cepsilon3 and alpha2 are the minimal units necessary for human IgE-FcepsilonRI interaction.免疫球蛋白样结构域Cepsilon3和alpha2是人类IgE与FcepsilonRI相互作用所必需的最小单位。
J Clin Invest. 1999 Jun;103(11):1571-8. doi: 10.1172/JCI6551.