Wegmann D R
Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA.
Curr Opin Immunol. 1996 Dec;8(6):860-4. doi: 10.1016/s0952-7915(96)80016-1.
Over the past year, a number of important observations have been made in the nonobese diabetic mouse and in clinical insulin-dependent diabetes mellitus concerning the autoimmune response to islets. Assays have advanced to the point where individuals at risk for insulin-dependent diabetes mellitus can be readily identified prior to the onset of symptoms and a number of peptides of proteins expressed by the beta cell have been shown to protect nonobese diabetic mice from developing diabetes. The contributions of CD4+ and CD8+ T cells to beta cell destruction are beginning to be understood and this information will probably be of value in the design of intervention strategies for use in human subjects.
在过去一年里，在非肥胖型糖尿病小鼠以及临床胰岛素依赖型糖尿病患者中，已经有了一些关于胰岛自身免疫反应的重要发现。检测技术已经发展到可以在症状出现之前轻易识别出胰岛素依赖型糖尿病高危个体的阶段，并且已经证明，β细胞表达的一些蛋白质肽可以保护非肥胖型糖尿病小鼠不患糖尿病。CD4+和CD8+ T细胞对β细胞破坏的作用开始得到了解，这些信息可能对设计用于人类受试者的干预策略具有重要价值。
