Markova E D, Gurskaia N Z, Nevskaia O M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(6):837-41.
The report contains a description of 3 families with disseminated sclerosis (2 siblings in each family). The detected changes in the immunological reactivity of these patients are correlated with the data of the previously studied 112 patients with disseminated sclerosis and speaks in favour of a neuroallergical reaction, the important role of which in the pathogenesis of disseminated sclerosis is at present generally acknowledged. Having in view the heredity of developing allergic reactions the authors suggest that there is a certain relation between the state of the immunocompetent systems and the predispositional factors in disseminated sclerosis. This serves as a basis for the assumption that disseminated sclerosis can be attributed to diseases with a hereditary predisposition where for the manifestation of the disease there should be an effect of exogenous (viral?) factors.
该报告描述了3个患有播散性硬化症的家庭（每个家庭中有2名兄弟姐妹）。这些患者免疫反应性的检测变化与之前研究的112例播散性硬化症患者的数据相关，支持了神经过敏反应的观点，目前普遍认为神经过敏反应在播散性硬化症的发病机制中起着重要作用。考虑到过敏反应的遗传性，作者认为免疫活性系统的状态与播散性硬化症的易患因素之间存在一定关系。这为以下假设提供了依据：播散性硬化症可归因于具有遗传易感性的疾病，这类疾病的表现需要外源性（病毒？）因素的作用。
