Panov A G, Shamreĭ R K
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(2):161-70.
In 30 patients with disseminated sclerosis (more than 500 sera) the authors studied autoantibodies in Steffen's reaction to different homologous antigens of normal and "pathological" brain and to some internal organs. A normal brain tissue appeared to be immunologically more differentiated than the tissues of patients who had died of disseminated sclerosis. The antigen properties of the white matter of frontal lobes were more expressed than the gray matter, subcortical nodes, tissues of the cerebellum and spinal cord. Gliose-changed nervous tissues are immunologically not active. There was a certain parallelism between the supposed focal substrate of neurological symptoms and the data of autoimmune reactions which may have a topico-diagnostic significance. The authors discuss the antibrain antibodies found in disseminated sclerosis from the concept of their preventive function.
在30例播散性硬化症患者（超过500份血清）中，作者研究了在对正常和“病理性”脑的不同同源抗原以及一些内脏器官的施特芬反应中的自身抗体。正常脑组织在免疫方面似乎比死于播散性硬化症患者的组织更具差异性。额叶白质的抗原特性比灰质、皮质下神经节、小脑和脊髓组织更明显。发生胶质变性的神经组织在免疫方面不活跃。神经症状的假定局灶性基质与自身免疫反应的数据之间存在一定的平行关系，这可能具有局部诊断意义。作者从其预防功能的概念出发讨论了在播散性硬化症中发现的抗脑抗体。
