[Role of clinical and pharmacokinetic parameters in predicting the effectiveness of lithium salts in patients with affective psychoses].

Prophylactic treatment with common preparations of lithium carbonate and in its retarded form was given to 44 patients. The studies demonstrated an inverse correlation between the level of negative changes in the patients and the effect of treatment. The use of different methods of mathematical models demonstrated that in the group of patients who received lithium carbonate the most informative was the index of the half-life period and the period of half-elimination of lithium. It was demonstrated that the higher the indices, the better the effect of treatment. In administration of retarded lithium the most informative was the integral index of elimination of the preparation from the organism (an inverse correlation with the effectiveness of therapy).