Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit.

The chromosome locations of the rabbit (Oryctolagus cuniculus) Na+-phosphate cotransporter genes NPT1 and NPT2 were determined by fluorescence in situ hybridization. Our results localize NPT1 to rabbit chromosome 12p11 and NPT2 to rabbit chromosome 3p11. The corresponding genes in the human map to chromosome bands 6p22 and 5q35, respectively. These assignments agree with the previously reported homology between rabbit chromosome 12 and human chromosome 6 and provide the basis for the establishment of a conserved syntenic group between rabbit chromosome 3 and human chromosome 5.