Haapaniemi H, Hillbom M, Juvela S
Department of Neurology, Oulu University Hospital, Finland.
Stroke. 1997 Jan;28(1):26-30. doi: 10.1161/01.str.28.1.26.
This study was designed to identify whether cigarette smoking, alcohol drinking, obesity, and use of oral contraceptives are independent risk factors for brain infarction among persons of working age.
Health habits and previous diseases of 506 patients (366 men and 140 women aged 16 to 60 years) with acute first-ever symptomatic brain infarction were compared with those of 345 hospitalized control patients (219 men and 126 women) who did not differ from case subjects in respect to day of onset of symptoms or acuteness of disease onset. With the use of stepwise logistic regression, the variables for which the simultaneous risks of acute brain infarction were tested by sex were age, amount of alcohol consumed within 24 hours and 1 week before the illness, heavy drinking, smoking status, current smoking, cardiac disease, hypertension, diabetes, hyperlipemia, migraine, body mass index, and, in women, current use of oral contraceptives.
Intake of > 40 g ethanol within the 24 hours preceding the onset of illness increased the risk for acute brain infarction both among men (P < .001) and women (P < .01) independently from other risk factors. Other significant independent risk factors for brain infarction among men were hypertension (P < .001), cardiac disease (P < .01), current smoking (P < .01), diabetes (P < .05), and history of migraine (P < .05) and among women, current use of oral contraceptives (P < .01) and current smoking (P < .05).
Recent heavy drinking of alcohol, hypertension, cardiac disease, current smoking, diabetes, and history of migraine among men, and recent heavy drinking of alcohol, current use of oral contraceptives, and current smoking among women, seem to be independent risk factors for acute brain infarction.
本研究旨在确定吸烟、饮酒、肥胖及口服避孕药的使用是否为工作年龄人群脑梗死的独立危险因素。
将506例首次发生急性症状性脑梗死患者（366例男性和140例女性，年龄16至60岁）的健康习惯和既往疾病，与345例住院对照患者（219例男性和126例女性）进行比较，这些对照患者在症状发作日或疾病发作急性程度方面与病例组无差异。通过逐步逻辑回归分析，按性别检验急性脑梗死同时存在风险的变量包括年龄、发病前24小时及1周内饮酒量、酗酒、吸烟状况、当前吸烟情况、心脏病、高血压、糖尿病、高脂血症、偏头痛、体重指数，对于女性还包括当前口服避孕药的使用情况。
发病前24小时内摄入乙醇超过40克，无论男性（P <.001）还是女性（P <.01），均独立于其他危险因素增加急性脑梗死风险。男性脑梗死的其他显著独立危险因素为高血压（P <.001）、心脏病（P <.01）、当前吸烟（P <.01）、糖尿病（P <.05）及偏头痛病史（P <.05）；女性脑梗死的其他显著独立危险因素为当前口服避孕药的使用（P <.01）及当前吸烟（P <.05）。
男性近期大量饮酒、高血压、心脏病、当前吸烟状况、糖尿病及偏头痛病史，以及女性近期大量饮酒、当前口服避孕药的使用及当前吸烟状况，似乎是急性脑梗死的独立危险因素。
