Tontisirin O, Rojanasakul A, Srisombut C, Wongkularb A, Chatasingh S
Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
J Med Assoc Thai. 1996 Oct;79(10):618-23.
The purposes of this study were to determine the efficacy of propofol anesthesia for oocyte retrieval and its effect on IVF outcomes. The anesthetic records of 339 oocyte retrieval cycles were analysed. The mean of total amount of propofol, duration of anesthesia and oocyte pick up were 197.7 +/- 84.2 mg, 25.2 +/- 8.5 and 19.5 +/- 7.4 minutes, respectively. In all cases propofol induced anesthesia within seconds. Mean recovery time was 32.2 +/- 5.4 minutes. Significant nausea and vomiting occurred in one patient. Mild hypotension was observed in 55 out of 339 cycles (16.2%) which did not correlate to the amount and duration of propofol used. A total of 3,417 oocytes were obtained. Fertilization occurred in 2,431 oocytes (71.1%). Mean cleavage rate was 84.5 per cent of fertilized eggs. Mean number of transferred embryo was 4.4 +/- 2.0. Embryos were transferred in 321 cycles, resulted in 73 pregnancies (21.5% per oocyte pick up and 22.7% per transfer). Neither the dose of propofol or the duration of anesthesia has significant effect on pregnancy rate. Propofol anesthesia was found to be efficacious for oocyte retrieval with a rapid induction and recovery, and minimal side effects. The fertilization and pregnancy rates are comparable to other reports using different anesthetic or analgesic agents. However, to reliably determine if propofol affects the IVF outcome a prospective and randomized trial should be performed.
本研究的目的是确定丙泊酚麻醉用于取卵的疗效及其对体外受精（IVF）结局的影响。分析了339个取卵周期的麻醉记录。丙泊酚总量的平均值、麻醉持续时间和取卵时间分别为197.7±84.2毫克、25.2±8.5分钟和19.5±7.4分钟。在所有病例中，丙泊酚在数秒内即可诱导麻醉。平均恢复时间为32.2±5.4分钟。1例患者出现明显恶心和呕吐。在339个周期中的55个（16.2%）观察到轻度低血压，这与丙泊酚的用量和持续时间无关。共获得3417个卵母细胞。2431个卵母细胞（71.1%）发生受精。平均卵裂率为受精卵的84.5%。平均移植胚胎数为4.4±2.0。321个周期进行了胚胎移植，结果有73例妊娠（每次取卵妊娠率为21.5%，每次移植妊娠率为22.7%）。丙泊酚的剂量或麻醉持续时间对妊娠率均无显著影响。发现丙泊酚麻醉用于取卵有效，诱导和恢复迅速，且副作用最小。受精率和妊娠率与使用不同麻醉或镇痛剂的其他报告相当。然而，为了可靠地确定丙泊酚是否影响IVF结局，应进行一项前瞻性随机试验。
