皮质类固醇激素对未成熟妊娠小鼠骨骺生长中心的影响。

Effects of corticosteroid hormone on the epiphyseal growth center of immature pregnant mice.

作者信息

Silbermann M, Levitan S

出版信息

Acta Anat (Basel). 1977;99(4):403-13. doi: 10.1159/000144863.

Abstract

Immature pregnant mice treated with glucocorticoid hormone (triamcinolone hexacetonide) were killed 1 week following delivery. The epiphyseal growth plates of the humerus and their cellular constituents were analyzed quantitatively. It became evident that pregnancy per se evokes a marked suppressive effect upon young cartilage cells, thus interfering with the normal process of endochondral bone formation. Pregnant mice treated with glucocorticoid hormone experienced an even higher degree of chondrocytic derangement, however, to a lesser extent than chondroxytes of nonpregnant mice treated with the hormone. It therefore appears that pregnancy-induced elevation of systemic estrogens and progesterone provides some kind of a protection against the antianabolic activity of glucocorticoids upon chondrocytes.

摘要

用糖皮质激素（己曲安奈德）处理的未成熟怀孕小鼠在分娩后1周处死。对肱骨的骨骺生长板及其细胞成分进行定量分析。结果表明，怀孕本身对年轻软骨细胞产生显著的抑制作用，从而干扰软骨内骨形成的正常过程。然而，用糖皮质激素处理的怀孕小鼠软骨细胞紊乱程度更高，但程度低于用该激素处理的未怀孕小鼠的软骨细胞。因此，似乎怀孕引起的全身雌激素和孕酮升高对糖皮质激素对软骨细胞的抗合成代谢活性提供了某种保护。