Lee H K, Kim D S, Noh G W, Lee K Y
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1996 Oct;37(5):357-63. doi: 10.3349/ymj.1996.37.5.357.
The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
在一项静脉注射免疫球蛋白（IVIG）联合阿司匹林与单用阿司匹林的随机试验中，研究了IVIG对急性川崎病（KD）淋巴细胞表型的影响。治疗前，每个治疗组的患者B细胞百分比增加，而T细胞、CD4 T细胞、CD8 T细胞和CD5+B细胞百分比降低。治疗前两组间的免疫参数无显著差异。接受IVIG联合阿司匹林治疗的患者在第4天时，T细胞、CD4 T细胞和CD8 T细胞显著增加，B细胞减少。尽管B细胞减少，但两个治疗组的CD5+B细胞均显著增加。然而，IVIG联合阿司匹林治疗组的增加程度明显比单用阿司匹林治疗组更显著。这些发现表明，IVIG治疗可恢复急性KD患者中发现的T细胞和B细胞异常，尤其是CD5+B细胞异常。
