DeVault K R, Beacham S, Castell D O, Streletz L J, Ditunno J F
Department of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA.
Am J Physiol. 1996 Dec;271(6 Pt 1):G937-41. doi: 10.1152/ajpgi.1996.271.6.G937.
We sought to determine the esophageal sensory function in patients with a C6 or C7 spinal cord injury. A balloon was repetitively distended 10 cm above the lower esophageal sphincter in five patients and nine normal control subjects. Sensation was reported on a scale from 0 to 2 with progressive distension to pain threshold (level 2). Cortical responses were recorded from midline scalp electrodes. Blinded determinations of quality and reproducibility of the potentials were performed. All subjects experienced sensation with esophageal balloon distension. Volumes to sensation showed a trend toward a higher sensory threshold in patients but were significant only for first sensation, not pain. In all subjects, a triphasic evoked potential response consisting of a negative-positive-negative complex was noted with distension but not with sham distension. Characteristics (amplitude, latency, reproducibility, and quality) of the evoked potentials were not different in patient and control groups. These data suggest sensory pathways from the distal esophagus are intact in patients with a C6 or C7 spinal cord injury.
我们试图确定C6或C7脊髓损伤患者的食管感觉功能。在5例患者和9名正常对照受试者中，将一个球囊在下食管括约肌上方10厘米处反复扩张。随着球囊逐渐扩张至疼痛阈值（2级），受试者根据0至2的量表报告感觉。从中线头皮电极记录皮质反应。对电位的质量和可重复性进行盲法测定。所有受试者在食管球囊扩张时均有感觉。产生感觉所需的容积显示患者的感觉阈值有升高趋势，但仅在首次感觉时显著，疼痛时不显著。在所有受试者中，球囊扩张时可观察到由负-正-负复合波组成的三相诱发电位反应，而假扩张时则未观察到。患者组和对照组诱发电位的特征（振幅、潜伏期、可重复性和质量）没有差异。这些数据表明，C6或C7脊髓损伤患者远端食管的感觉通路是完整的。
