Stehling O, Döring H, Ertl J, Preibisch G, Schmidt I
Max-Planck-Institut für physiologische und klinische Forschung, W. G. Kerckhoff-Institut, Bad Nauheim, Germany.
Am J Physiol. 1996 Dec;271(6 Pt 2):R1770-4. doi: 10.1152/ajpregu.1996.271.6.R1770.
The recently identified hormone leptin (ob protein) secreted by white adipose tissue is widely thought to provide a feedback signal limiting fat storage by decreasing food intake. By artificially rearing leptin-treated and control littermates fed identical amounts of milk, however, we show here that lean suckling-age rats treated with recombinant murine leptin can reduce fat storage solely by increasing energy expenditure. Continuous measurements of core temperature and metabolic rate show that this increase is not uniform throughout the day but is especially prominent in the morning when rat pups usually conserve energy by entering a torpor-like state. Leptin's alleviation of hypometabolic, torpor-like states is thus not restricted to cases of impaired hormone production but seems instead to be a normal biological function independent of its effects on food intake.
最近发现的由白色脂肪组织分泌的激素瘦素（肥胖蛋白）被广泛认为通过减少食物摄入量来提供一个限制脂肪储存的反馈信号。然而，通过人工饲养接受相同量牛奶喂养的经瘦素处理的同窝幼崽和对照同窝幼崽，我们在此表明，用重组鼠瘦素处理的瘦的哺乳期大鼠仅通过增加能量消耗就能减少脂肪储存。对核心体温和代谢率的连续测量表明，这种增加在一天中并不均匀，而是在早晨尤为显著，此时幼鼠通常通过进入类似蛰伏的状态来保存能量。因此，瘦素对低代谢、类似蛰伏状态的缓解并不局限于激素产生受损的情况，相反，这似乎是一种独立于其对食物摄入影响的正常生物学功能。
