Döring H, Schwarzer K, Nuesslein-Hildesheim B, Schmidt I
Max-Planck-Institut für physiologische und klinische Forschung, WG Kerckhoff-Institut, Bad Nauheim, FRG.
Int J Obes Relat Metab Disord. 1998 Feb;22(2):83-8. doi: 10.1038/sj.ijo.0800547.
To find out whether leptin can attenuate hypometabolic torpor-like states of metabolic rate (MR) in adult lean animals, as it attenuates the morning suppression of thermoregulatory thermogenesis in suckling-age rat pups.
Leptin effects on MR and food intake were studied in mice aged 4-7 months, in which a high incidence of exaggerated circadian reductions of MR had been induced by chronic food-restriction and, for comparison, in free-feeding mice.
Continuous recordings of MR, for a group of seven mice maintained at an ambient temperature of 24 degrees C, while they were repeatedly-with pauses of at least six days-treated for three consecutive days with either recombinant murine leptin (20, 200 or 600 pmol x g(-1) x d[-1]) or saline.
Leptin treatment caused dose-dependent 5-15% increases in energy expenditure by moderating the decreases in MR during the circadian minima, without affecting either the MR during the circadian maxima or food intake. Similar treatment of free-feeding mice caused dose-dependent decreases of food intake without changing MR.
Leptin controls thermoregulatory energy expenditure when food supplies are scarce and changes food intake, rather than energy expenditure, when food is abundant.
研究瘦素是否能减轻成年瘦动物代谢率（MR）的低代谢类蛰伏状态，因为它能减轻哺乳龄大鼠幼崽体温调节性产热的早晨抑制。
在4 - 7月龄小鼠中研究瘦素对MR和食物摄入量的影响，这些小鼠因长期食物限制而出现高发生率的MR昼夜节律性过度降低，作为对照，同时研究自由进食小鼠。
将一组7只小鼠置于24摄氏度的环境温度下，连续记录MR，期间它们被反复（间隔至少6天）用重组鼠瘦素（20、200或600 pmol·g⁻¹·d⁻¹）或生理盐水连续处理3天。
瘦素处理通过减轻昼夜节律最低点时MR的下降，使能量消耗呈剂量依赖性增加5% - 15%，而不影响昼夜节律最高点时的MR或食物摄入量。对自由进食小鼠进行类似处理会导致食物摄入量呈剂量依赖性减少，但不改变MR。
当食物供应不足时，瘦素控制体温调节性能量消耗；当食物充足时，瘦素改变食物摄入量，而非能量消耗。
