Powell H C, Marshall L F, Ignelzi R J
Acta Neuropathol. 1977 Aug 16;39(2):165-7. doi: 10.1007/BF00703323.
A fibrosarcoma developed in the pituitary fossa of a patient who had been irradiated 13 years previously for treatment of pituitary adenoma. The tumor was a large aggressively growing spindle cell neoplasm which eroded adjacent structures, causing increased intracranial pressure, and eventual cerebellar tonsillar herniation. In common with previously described post-irradiation sarcoma of the pituitary, this lesion developed in the path of irradiation after a long latent period, did not metastasize, and contained histologically recognizable benign appearing pituitary adenoma interspersed among the spindle cell tumor. The dose of radiation (5000 rads) also lay within the range associated with sarcomatous transformation.
一名患者13年前因垂体腺瘤接受放疗，之后在垂体窝处发生了纤维肉瘤。该肿瘤是一个大型的、生长迅速的梭形细胞瘤，侵蚀邻近结构，导致颅内压升高，最终出现小脑扁桃体疝。与先前描述的垂体放疗后肉瘤一样，该病变在放疗路径上经过很长的潜伏期后发生，未发生转移，并且在梭形细胞瘤中散在分布着组织学上可识别的外观良性的垂体腺瘤。放疗剂量（5000拉德）也在与肉瘤转化相关的范围内。
