Axelsson A, Hallén O, Miller J M, McPherson D L
Acta Otolaryngol. 1977 Jul-Aug;84(1-2):1-11. doi: 10.3109/00016487709123937.
This investigation confirmed previous studies indicating that the middle and inner ear of the guinea pig have a pronounced tendency to healing. Middle ear hemorrhage of surgical origin appears to stop quickly in the guinea pig. A surgically created perforation of the round window with or without removal of perilymphatic fluid by suction resulted in a spontaneous healing of the round window membrane in 12/13 animals. Perilymphatic hemorrhage, associated with short post-surgical interval was found in a substantial number of cases. The origin of the perilymphatic hemorrhage is doubtful. Degeneration of the organ of Corti was found in four ears in three animals and appeared to be correlated to the perilymphatic hemorrhage. Electrophysiological measurements appeared to correlate well with the anatomical findings for one animal with very small changes and for three animals with pronounced middle and inner ear pathology. In three additional animals less agreement was observed. In general these animals showed a more pronounced decrease of function than would be expected by the anatomy.
本研究证实了先前的研究结果，即豚鼠的中耳和内耳具有明显的愈合倾向。手术引起的中耳出血在豚鼠中似乎会迅速停止。通过手术造成圆窗穿孔，无论是否通过吸引去除外淋巴液，13只动物中有12只的圆窗膜实现了自发愈合。在大量病例中发现了与术后短时间间隔相关的外淋巴出血。外淋巴出血的起源尚不确定。在三只动物的四只耳朵中发现了柯蒂氏器变性，这似乎与外淋巴出血有关。对于一只变化非常小的动物以及三只中耳和内耳病变明显的动物，电生理测量结果似乎与解剖学发现密切相关。在另外三只动物中，观察到的一致性较差。总体而言，这些动物的功能下降比解剖学预期的更为明显。
