Dixon S C, Soriano B J, Lush R M, Borner M M, Figg W D
Clinical Pharmacokinetics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ann Pharmacother. 1997 Jan;31(1):76-82. doi: 10.1177/106002809703100113.
To review the current literature regarding the role of apoptosis in the development of malignant cells and how the induction of this pathway could be used in cancer therapy.
A MEDLINE search of basic science articles pertinent to the understanding of the normal physiologic process of apoptosis was conducted.
Because of the rapidly growing literature regarding apoptosis, only articles describing key processes in the biology of the cell and the genetic control of apoptosis were included.
Apoptosis is imperative for host survival since it discards unwanted, damaged, and atypical cells. The process is therefore implicated in the continuous regulation of development, differentiation, and homeostasis. Furthermore, apoptosis is a response to physiologic and pathologic stresses that disrupt the balanced rates of cell generation and elimination. In a disease such as cancer, there is a lack of equilibrium between the rates of cell division and cell death; agents that promote or suppress apoptosis can manipulate these rates, influencing the anomalous accumulation of neoplastic cells. Pharmacologic manipulation of apoptosis can manipulate these rates, influencing the anomalous accumulation represents a novel approach in targeting malignant cells and has far-reaching implications for new directions in cancer therapy.
Apoptosis is a highly organized physiologic mechanism of destroying injured and abnormal cells as well as maintaining homeostasis in multicellular organisms. Both the activation and inhibition of apoptosis are tightly controlled. Pharmacologic manipulation of this pathway is a novel therapeutic target in cancer therapy.
综述当前关于细胞凋亡在恶性细胞发展中的作用以及如何诱导该途径用于癌症治疗的文献。
对与理解细胞凋亡正常生理过程相关的基础科学文章进行了医学文献数据库（MEDLINE）检索。
由于关于细胞凋亡的文献迅速增加，仅纳入了描述细胞生物学关键过程和细胞凋亡基因调控的文章。
细胞凋亡对于宿主生存至关重要，因为它可清除不需要的、受损的和非典型细胞。因此，该过程与发育、分化和体内平衡的持续调节有关。此外，细胞凋亡是对破坏细胞生成和清除平衡速率的生理和病理应激的一种反应。在癌症等疾病中，细胞分裂和细胞死亡速率之间缺乏平衡；促进或抑制细胞凋亡的药物可操纵这些速率，影响肿瘤细胞的异常积累。对细胞凋亡进行药理学操纵可影响这些速率，针对恶性细胞的异常积累是一种靶向恶性细胞的新方法，对癌症治疗的新方向具有深远意义。
细胞凋亡是一种高度有组织的生理机制，用于破坏受损和异常细胞以及维持多细胞生物体的体内平衡。细胞凋亡的激活和抑制均受到严格控制。对该途径进行药理学操纵是癌症治疗中的一个新的治疗靶点。
