用于检测口腔液中丙型肝炎病毒抗体的改良酶免疫测定法。
Modified enzyme immunoassay to detect hepatitis C virus antibodies in oral fluid.
作者信息
McIntyre P G, Laszlo J, Appleyard K, Ogden G R
机构信息
Department of Medical, Microbiology, Ninewells Hospital, Dundee, UK.
出版信息
Eur J Clin Microbiol Infect Dis. 1996 Nov;15(11):882-4. doi: 10.1007/BF01691223.
Samples of oral fluid collected from 18 patients seropositive for hepatitis C virus (HCV) and 49 seronegative patients were tested for the presence of HCV antibodies with two modified serum-screening kits. The following sensitivities and specificities were obtained: HCV 3.0 assay, 72% and 98%, respectively, and Monolisa anti-HCV assay, 100%, and 100%, respectively. The modified Monolisa assay demonstrated a striking concordance between serum and saliva samples. The use of oral fluids offers a convenient and noninvasive method applicable to HCV epidemiological studies and screening of high-risk groups.
使用两种改良的血清筛查试剂盒，对18例丙型肝炎病毒（HCV）血清学阳性患者和49例血清学阴性患者采集的口腔液样本进行HCV抗体检测。获得了以下灵敏度和特异性：HCV 3.0检测分别为72%和98%，以及Monolisa抗HCV检测分别为100%和100%。改良的Monolisa检测显示血清和唾液样本之间有显著的一致性。使用口腔液提供了一种适用于HCV流行病学研究和高危人群筛查的便捷且无创的方法。
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