Shulman D G, Sargent J B, Stewart R H, Mester U
Houston Eye Associates, Texas, USA.
Eur J Ophthalmol. 1996 Oct-Dec;6(4):361-7. doi: 10.1177/112067219600600403.
The effects of four days' treatment with topical Maxitrol (neomycin sulphate 3500 IU/mL, polymyxin-B sulphate 6000 IU/mL with dexamethasone 0.1%) were compared with those of Maxidex (dexamethasone 0.1% alone) in a double-masked study in 111 patients with bacterial blepharitis or conjunctivitis, 95 of whom were evaluable for efficacy. The majority of patients (N = 80) had chronic blepharitis. Maxitrol treatment resulted in a significantly greater reduction (90%) in bacterial counts and bacterial eradication (50%) compared with Maxidex (34% and 17% respectively). Maxitrol treatment also produced a significantly greater reduction in conjunctival discharge than did Maxidex, while the treatments were equally effective in alleviating other ocular signs and symptoms. It was concluded that use of a fixed dose combination steroid-antibiotic product was more effective for bacterial control and therapeutic efficacy in the treatment of chronic blepharitis and conjunctivitis patients than treatment with steroid alone. However, in the long-term treatment of chronic blepharitis the well-known toxic problems of neomycin sulphate have to be taken into account.
在一项针对111例细菌性睑缘炎或结膜炎患者的双盲研究中，比较了局部使用Maxitrol（硫酸新霉素3500 IU/mL、硫酸多粘菌素B 6000 IU/mL与0.1%地塞米松）治疗四天的效果与Maxidex（仅0.1%地塞米松）的效果，其中95例患者可评估疗效。大多数患者（N = 80）患有慢性睑缘炎。与Maxidex相比，Maxitrol治疗使细菌计数显著降低（90%），细菌清除率显著提高（50%）（分别为34%和17%）。Maxitrol治疗还使结膜分泌物比Maxidex显著减少，而两种治疗在缓解其他眼部体征和症状方面同样有效。得出的结论是，对于慢性睑缘炎和结膜炎患者，使用固定剂量的类固醇 - 抗生素联合产品在细菌控制和治疗效果方面比单独使用类固醇治疗更有效。然而，在慢性睑缘炎的长期治疗中，必须考虑硫酸新霉素众所周知的毒性问题。
