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槲皮素与热休克之间的相互作用:对鸡胚的初步研究

Interaction between quercetin and heat shock. A preliminary study on the chick embryo.

作者信息

Janoutová J, Buckiová D, Jelínek R

机构信息

Institute of Histology and Embryology, 3rd Medical Faculty, Charles University, Prague, Czech Republic.

出版信息

Folia Biol (Praha). 1996;42(5):231-4.

PMID:8997640
Abstract

A hyperthermic shock (43 degrees C/30 min) enhances in somite stages of the chick embryo development the activity of the caudal morphogenetic system, manifested by intensive growth of the embryonic trunk. The exposure also induced the synthesis of heat shock proteins (HSP 70). A single administration of a bioflavonoid quercetin dissolved in DMSO to chick embryos in stages HH 10-11 (10-14 somites) prior to heat exposure inhibited both the growth acceleration and the HSP induction.

摘要

热休克(43摄氏度/30分钟)可增强鸡胚发育体节期尾端形态发生系统的活性,表现为胚胎躯干的强烈生长。这种暴露还诱导了热休克蛋白(HSP 70)的合成。在热暴露前,向HH 10-11期(10-14个体节)的鸡胚单次施用溶解于二甲基亚砜的生物类黄酮槲皮素,可抑制生长加速和HSP诱导。

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