Zubillaga M B, Boccio J R, Nicolini J O, Ughetti R, Lanari E, Caro R A
Radioisotope Laboratory, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1996;46(2):103-10.
With the purpose of studying the effectivity of an intratumoral single dose of chromic [32P] phosphate with great particles for the treatment of solid tumors, studies of bioelimination, biodistribution and therapeutic action were carried out. Only for comparative purposes, similar studies were undertaken using a solution of sodium -32P- orthophosphate-gelatine. The results show that when sodium [32P] orthophosphate-gelatine is used, the percentage of total elimination is (85.90 +/- 8.70)% with a higher percentage in urine (64.50 +/- 13.70)% than in faeces (21.40 +/- 4.50)%. In biodistribution studies, the greater percentage is found in bone (15.54 +/- 2.21)% while only a (2.51 +/- 0.39)% remains in the tumor. When great particles chromic [32P]phosphate was intratumorally injected, we determined that the total elimination is equal (36.28 +/- 6.27)%, finding a higher amount in faeces (29.44 +/- 5.26)% than in urine (6.84 +/- 2.21)%. Biodistribution studies demonstrated that (49.82 +/- 5.41)% remains in the tumor and (9.63 +/- 4.89)% of the injected activity is found in the liver. On the other hand, when therapeutic action was evaluated, we observed that the percentage of tumor regression (P.T.R.) is 52.0% for the tumors injected with chromic [32P]phosphate and 0.0% for those injected with sodium [32P]orthophosphate-gelatine. These results show that the great particles colloid of chromic [32P]phosphate is not safe enough for the treatment of solid tumors, since it is mobilized from the injection point, delivering a high dose to the whole organism.
为研究瘤内单次注射大颗粒铬[32P]磷酸盐治疗实体瘤的有效性，进行了生物消除、生物分布及治疗作用的研究。仅为作比较，使用32P -正磷酸钠 -明胶溶液进行了类似研究。结果表明，使用32P -正磷酸钠 -明胶时，总消除百分比为(85.90±8.70)%，其中尿液中占比更高(64.50±13.70)%，粪便中占(21.40±4.50)%。在生物分布研究中，骨中占比最大(15.54±2.21)%，而肿瘤中仅残留(2.51±0.39)%。当瘤内注射大颗粒铬[32P]磷酸盐时，我们测定总消除量为(36.28±6.27)%，粪便中含量高于尿液(粪便中为29.44±5.26)%，尿液中为(6.84±2.21)%。生物分布研究表明，(49.82±5.41)%残留于肿瘤中，肝脏中发现注入活性的(9.63±4.89)%。另一方面，在评估治疗作用时，我们观察到注射铬[32P]磷酸盐的肿瘤的肿瘤消退百分比(P.T.R.)为52.0%，而注射32P -正磷酸钠 -明胶的肿瘤为0.0%。这些结果表明，铬[32P]磷酸盐大颗粒胶体对实体瘤治疗的安全性不足，因为它会从注射点移动，向整个机体输送高剂量。
