Gordina G A
NII of Pediatric Oncology, ONTs RAMN, Moscow.
Vestn Ross Akad Med Nauk. 1996(10):23-5.
From 1982 to 1991, a total of 132 children with lymphogranulomatosis involving the mediastinum were studied. The comparative analysis of their survival was made on the basis of clinical and laboratory findings which might affect prognosis. Factorial analysis identified 9 unfavourable factors significantly influencing the survival rates. Their predictive value was defined from the informative rate (IR) and distributed in the following decreasing order: patient incompliance, Stage IV, the mediastinal thoracic index of more than 50%, the histological types: modular sclerosis and lymphoid depletion, the patient age of over 10 years, higher haptoglobulin and ceruloplasmin levels, leukocytosis (greater than 8 x 10(9)) g/l, diseases of the lung and pleura. The findings show it expedient to consider the above unfavorable factors in defining a risk group to apply a differential approach to treating patients with lymphogranulomatosis involving the mediastinum.
1982年至1991年，共研究了132例累及纵隔的淋巴肉芽肿病患儿。根据可能影响预后的临床和实验室检查结果，对其生存率进行了比较分析。因子分析确定了9个显著影响生存率的不利因素。根据信息率（IR）确定了它们的预测价值，并按以下降序排列：患者依从性差、IV期、纵隔胸廓指数超过50%、组织学类型：结节硬化和淋巴细胞耗竭、患者年龄超过10岁、触珠蛋白和铜蓝蛋白水平较高、白细胞增多（大于8×10⁹/L）、肺部和胸膜疾病。研究结果表明，在确定风险组以对累及纵隔的淋巴肉芽肿病患者采用差异化治疗方法时，考虑上述不利因素是适宜的。
