Anderson H, Jenkins J P, Brigg D J, Deakin D P, Palmer M K, Todd I D, Crowther D
Clin Radiol. 1985 Sep;36(5):449-54. doi: 10.1016/s0009-9260(85)80183-5.
Three hundred and two previously untreated patients with Stage IA-IVB Hodgkin's disease were reviewed to determine the prognostic significance of mediastinal involvement. Mediastinal bulk disease was defined as either a maximal mediastinal width of 7.5 cm or more, or a ratio of the maximum width of mediastinal disease to the maximum chest diameter of greater than or equal to 0.33, or a ratio of the maximum width of mediastinal disease to the chest diameter at T5-T6 greater than or equal to 0.33, or as an area of mediastinal disease greater than or equal to 100 cm2. Bulk disease outside the chest was defined as a mass of lymph nodes measuring 5 cm or more in any axis. The presence of mediastinal bulk disease was of adverse prognostic significance for remission duration and survival in patients with Stage IA-IIB Hodgkin's disease, but for patients with more advanced disease the effect of mediastinal bulk on remission duration and survival was not statistically significant. The mediastinal bulk variable which most significantly related to prognosis was the ratio of the maximum mediastinal disease to the chest diameter at T5-T6.
对302例未经治疗的ⅠA - ⅣB期霍奇金病患者进行回顾性研究，以确定纵隔受累的预后意义。纵隔肿块性病变定义为：最大纵隔宽度≥7.5 cm；或纵隔病变最大宽度与胸部最大直径之比≥0.33；或纵隔病变最大宽度与T5 - T6水平胸部直径之比≥0.33；或纵隔病变面积≥100 cm²。胸部外肿块性病变定义为任一径线≥5 cm的淋巴结肿块。纵隔肿块性病变对ⅠA - ⅡB期霍奇金病患者的缓解期和生存期具有不良预后意义，但对病情更晚期的患者，纵隔肿块对缓解期和生存期的影响无统计学意义。与预后最显著相关的纵隔肿块变量是纵隔病变最大宽度与T5 - T6水平胸部直径之比。
