Flusser D, Zylber-Katz E, Granit L, Levy M
Clinical Pharmacology Unit, Hadassah University Hospital, Jerusalem, Israel.
Eur J Clin Pharmacol. 1988;34(1):105-7. doi: 10.1007/BF01061429.
Twelve healthy volunteers were given a single oral dose of dipyrone 1 g, once while fasting and once after a standard breakfast. Plasma levels of the active dipyrone metabolite-Methylaminoantipyrine (MAA) were measured and the calculated pharmacokinetic parameters were compared. Taking dipyrone with food resulted in a small delay in the mean time to peak from 1.5 h to 1.9 h (p less than 0.01). However, there was no significant difference in AUC, Cmax or K(elim) between fasting and nonfasting conditions. The rate of absorption, expressed as the mean K(abs), was somewhat slower in the nonfasting state, but not significantly so. It is suggested that dipyrone may be taken regardless of the times of eating.
12名健康志愿者单次口服1克安乃近，一次在空腹时，一次在标准早餐后。测量了活性安乃近代谢物甲氨基安替比林（MAA）的血浆水平，并比较了计算出的药代动力学参数。进食时服用安乃近导致平均达峰时间略有延迟，从1.5小时延迟至1.9小时（p<0.01）。然而，空腹和非空腹条件下的AUC、Cmax或K（消除）无显著差异。以平均K（吸收）表示的吸收速率在非空腹状态下稍慢，但差异不显著。建议无论进食时间如何均可服用安乃近。
