Martiana K, Low C K, Tan S K, Pang M W
Department of Orthopaedic O, Singapore General Hospital.
Clin Orthop Relat Res. 1996 Apr(325):218-24. doi: 10.1097/00003086-199604000-00026.
Various interpositional materials, except muscle, have been used to prevent transphyseal bone bridge formation after resection of the damaged physeal plate. In this animal model, muscle was used as an interpositional material, and its effectiveness was compared with that of 3 known materials (fat, physeal allograft, and iliac apophyseal autograft). Five experiments were done on the distal femoral physis of 40 skeletally immature 3-month-old New Zealand white rabbits. The rabbits were divided into 5 groups, each containing 8 rabbits. A standard defect was created in the lateral distal physis of the left femur in all the rabbits. In Group A, there was no interpositional material. Vastus lateralis muscle, groin fat, physeal allograft, and iliac apophyseal autograft were inserted into the femoral defect in Groups B, C, D, and E, respectively. The right femur served as a sham control for the animals. The animals were sacrificed at 12 weeks after surgery. The results of limb length discrepancy and angular deformity of the groups with interpositional material were compared with those of Group A (experimental control). Muscle, fat, and iliac apophyseal autografts had less severe limb length discrepancy and angular deformity. These differences were statistically significant, whereas the differences between allograft and experimental control were statistically insignificant.
除肌肉外，多种植入材料已被用于防止受损生长板切除后经骺骨桥的形成。在这个动物模型中，肌肉被用作植入材料，并将其有效性与3种已知材料（脂肪、骨骺同种异体移植物和髂骨骨突自体移植物）进行比较。对40只3个月大骨骼未成熟的新西兰白兔的股骨远端生长板进行了5次实验。将兔子分为5组，每组8只。所有兔子的左股骨外侧远端生长板均制造标准缺损。A组不植入材料。B、C、D和E组分别将股外侧肌、腹股沟脂肪、骨骺同种异体移植物和髂骨骨突自体移植物植入股骨缺损处。右股骨作为动物的假对照。术后12周处死动物。将有植入材料组的肢体长度差异和角度畸形结果与A组（实验对照组）进行比较。肌肉、脂肪和髂骨骨突自体移植物的肢体长度差异和角度畸形较轻。这些差异具有统计学意义，而异种异体移植物与实验对照组之间的差异无统计学意义。
