Gaschignard N, Letessier E, Hamy A, Sagan C, Cuillière P, Courant O, Paineau J, Visset J
Service de Chirurgie Générale I, Hôpital G. et R. Laennec, Nantes.
J Chir (Paris). 1996 Jul;133(5):201-7.
Histopathologic and clinical follow-up data of 17 patients observed 3-104 months (mean: 38 months) after operation for oncocytic tumors of the thyroid gland are presented. Mean patient age was 50 +/- 15 years. Benign and malignant lesions were respectively 13 and 4. Frozen sections were positive for benign and malignant lesions in respectively 7 and 2 cases. Total thyroidectomy was performed in all cases of malignant lesions and in 7 cases of benign lesion, the latter in order to treat high volume adenomas or associated controlateral lesions. No tumor relapse was observed during the follow-up period (data about 16 patients). A review of the literature indicates that thyroid oncocytic adenoma diagnosis can be trusted and that this tumor is not especially prone to a malignant course with the mode of treatment applied. Thus total thyroidectomy should be recommended for: 1) malignant tumors. 2) and for selected benign adenomas depending on the tumor volume or on associated lesions.
本文呈现了17例甲状腺嗜酸细胞瘤患者术后3 - 104个月(平均38个月)的组织病理学和临床随访数据。患者平均年龄为50±15岁。良性和恶性病变分别为13例和4例。冰冻切片显示,良性和恶性病变分别在7例和2例中呈阳性。所有恶性病变病例以及7例良性病变病例均进行了甲状腺全切除术,后者是为了治疗大体积腺瘤或相关的对侧病变。随访期间未观察到肿瘤复发(16例患者的数据)。文献回顾表明,甲状腺嗜酸细胞瘤的诊断是可靠的,并且采用所应用的治疗方式,这种肿瘤并非特别倾向于恶性病程。因此,对于以下情况应推荐甲状腺全切除术:1)恶性肿瘤。2)以及根据肿瘤体积或相关病变选择的良性腺瘤。