Araki A, Sendo F
Department of Immunology and Parasitology, Yamagata University School of Medicine, Japan.
Microbiol Immunol. 1996;40(5):333-8. doi: 10.1111/j.1348-0421.1996.tb01076.x.
In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the in vivo antibacterial activity of two other cephalosporins, cefpimizole (CPIZ) and cefoperazone (CPZ), was bilaterally affected by a rise or fall in the neutrophil number, although to a lesser degree than was the case with CDZM. Taken together, neutrophils play an important role in the in vivo antibacterial activity of certain cephalosporins.
为阐明头孢地嗪（CDZM）这种头孢菌素体内抗菌活性的机制，在通过单克隆抗体RP - 3选择性清除中性粒细胞的大鼠中，检测了该抗生素对铜绿假单胞菌E7感染的影响。在经RP - 3处理的大鼠中，CDZM的效果不如未处理的大鼠。然而，用重组人粒细胞集落刺激因子（rhG - CSF）治疗大鼠可增强该抗生素的体内活性。此外，另外两种头孢菌素头孢咪唑（CPIZ）和头孢哌酮（CPZ）的体内抗菌活性也受到中性粒细胞数量增减的双向影响，尽管程度低于CDZM的情况。综上所述，中性粒细胞在某些头孢菌素的体内抗菌活性中起重要作用。
