Patrassi G M, Toffanin F, Massa G, Schivazappa L, Girolami A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1979;106(3):414-25.
Several indices of plasmatic and platelet coagulability (H.T.C.T., AT III, fibrinogen and Wu-Hoak test) were studied in 82 patients with acute and chronic coronary artery disease. The results were compared with those obtained in a control group. The most interesting result is the consistent shortening of H.T.C.T. as compared to the control group, particularly in patients with acute myocardial infarction. H.T.C.T. was always inversely correlated with the fibrinogen level. Those data suggest an important influence of fibrinogen levels on H.T.C.T., but this observation does not rule out the possibility that the heparin neutralizing activity (PF 4) will also influence the test. No positive correlation between H.T.C.T. and AT III could be observed. The elevated levels of AT III in acute myocardial infarction did not confirm the existence of a consumption of AT III due to chronic intravascular coagulation in these patients. The Wu-Hoak test increased only in patients with acute coronary disease, never in the other groups. In conclusion, H.T.C.T. may be assumed to be a valid test for indicating the existence of a possible hypercoagulability state.
对82例急慢性冠状动脉疾病患者的多项血浆和血小板凝固性指标（血细胞比容、抗凝血酶III、纤维蛋白原和吴-霍克试验）进行了研究。将结果与对照组的结果进行了比较。最有趣的结果是，与对照组相比，血细胞比容持续缩短，尤其是急性心肌梗死患者。血细胞比容始终与纤维蛋白原水平呈负相关。这些数据表明纤维蛋白原水平对血细胞比容有重要影响，但这一观察结果并不排除肝素中和活性（PF 4）也会影响该试验的可能性。未观察到血细胞比容与抗凝血酶III之间存在正相关。急性心肌梗死患者抗凝血酶III水平升高并未证实这些患者因慢性血管内凝血而存在抗凝血酶III消耗的情况。吴-霍克试验仅在急性冠状动脉疾病患者中升高，在其他组中从未升高。总之，可以认为血细胞比容是一种有效的试验，用于指示可能存在的高凝状态。
