Kohnert K, Lerch H, Thelen M, Jürgens H, Schober O
Klinik und Poliklinik für Nuklcarmedizin, Westfälische Wilhelms-Universität Münster, Deutschland.
Nuklearmedizin. 1996 Dec;35(6):220-4.
The diagnostic value of 123I-mIBG-scintigraphy, bone scintigraphy and catecholamine metabolites in the follow up of neuroblastoma stage IV will be evaluated.
Nineteen children suffering from neuroblastoma were analysed retrospectively by 123I-mIBG-scintigraphy, bone scintigraphy and measurement of homovanillic acid, vanillic acid, neuronspecific enclose, lactate dehydrogenase, and ferritine. Follow up was 7-132 (median 36) months.
The significance of the methods was dependent on the time of diagnostic use. In principal, 123I-mIBG-scintigraphy has the highest diagnostic impact. For initial staging and diagnosis of recurrence a combination of all three methods can be used. On the contrary, follow up during chemotherapy is best documented by 123I-mIBG-scintigraphy, whereas bone scintigraphy is of limited and measurement of catecholamine metabolites of less diagnostic value.
评估123I-间碘苄胍闪烁扫描、骨闪烁扫描及儿茶酚胺代谢产物在IV期神经母细胞瘤随访中的诊断价值。
对19例神经母细胞瘤患儿进行回顾性分析，采用123I-间碘苄胍闪烁扫描、骨闪烁扫描，并测定高香草酸、香草酸、神经元特异性烯醇化酶、乳酸脱氢酶和铁蛋白。随访时间为7至132个月（中位数36个月）。
这些方法的意义取决于诊断使用的时间。原则上，123I-间碘苄胍闪烁扫描具有最高的诊断价值。对于初始分期和复发诊断，可联合使用这三种方法。相反，化疗期间的随访最好通过123I-间碘苄胍闪烁扫描记录，而骨闪烁扫描的价值有限，儿茶酚胺代谢产物的测定诊断价值较小。
