Elser H, Henze M, Spierer F J, Georgi P
Abteilung für Nuklearmedizin der Radiologischen Universitätsklinik Heidelberg, Deutschland.
Nuklearmedizin. 1996 Dec;35(6):243-50.
The aim of the study was to clarify, whether the selection of the reference-region and/or the reconstruction-filter influences the result of the semiquantitative analysis of a 99mTc-HMPAO-SPECT that was conducted to diagnose the dementia of the Alzheimer type (DAT).
A group of 19 DAT-patients according to the criteria of NINCDS-ADRDA and DSM-III-R was examined together with a comparison group (n = 14) with normal cerebral perfusion. Three reference-regions (cerebellum, whole slice, occipital cortex) and four reconstruction-filters (Hanning fc = 0.7 and 1.0 Nyquist; Butterworth (n = 8); fc = 0.5 and 0.9 Nyquist) were applied to twelve standardized regions of interest (per patient) respectively. The data was evaluated through a ROC-analysis.
It has been showed, that the bilateral parieto-temporal perfusion reduction as a characteristic of DAT depends on the filters and reference-regions used. The most secure separation of both groups of patients was obtained through a Butterworth-filter (n = 8; fc = 0.5) in combination with the cerebellum as reference-region.
The selection of the reference-region and the reconstruction-filter has an important influence on the results of a semiquantitative analysis. Therefore standardisation in dependency on the actual questioning is necessary.
本研究旨在阐明，在进行99mTc-HMPAO单光子发射计算机断层扫描（SPECT）以诊断阿尔茨海默病型痴呆（DAT）时，参考区域的选择和/或重建滤波器是否会影响半定量分析的结果。
根据美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会（NINCDS-ADRDA）和精神疾病诊断与统计手册第三版修订版（DSM-III-R）的标准，对一组19名DAT患者以及一组脑灌注正常的对照组（n = 14）进行了检查。分别将三个参考区域（小脑、全切片、枕叶皮质）和四个重建滤波器（汉宁滤波器，截止频率fc = 0.7和1.0奈奎斯特频率；巴特沃斯滤波器（n = 8）；截止频率fc = 0.5和0.9奈奎斯特频率）应用于十二个标准化感兴趣区域（每位患者）。通过受试者工作特征（ROC）分析对数据进行评估。
结果表明，作为DAT特征的双侧顶颞叶灌注减少取决于所使用的滤波器和参考区域。通过使用巴特沃斯滤波器（n = 8；fc = 0.5）并结合小脑作为参考区域，两组患者之间获得了最可靠的区分。
参考区域和重建滤波器的选择对半定量分析结果有重要影响。因此，有必要根据实际问题进行标准化。
