正常内侧颞叶中锝-99m-六甲基丙烯胺肟与锝-99m-双半胱乙酯的个体内差异。
Intra-individual differences between technetium-99m-HMPAO and technetium-99m-ECD in the normal medial temporal lobe.
作者信息
Oku N, Matsumoto M, Hashikawa K, Moriwaki H, Ishida M, Seike Y, Terakawa H, Watanabe Y, Uehara T, Nishimura T
机构信息
First Department of Medicine, Osaka University Medical School, Japan.
出版信息
J Nucl Med. 1997 Jul;38(7):1109-11.
UNLABELLED
Regional distributions of 99mTc-hexamethyl propyleneamine oxime (99mTc-HMPAO) and 99mTc-ethyl cysteinate dimer (99mTc-ECD) were compared in the normal brain.
METHODS
Six paid, healthy volunteers (mean age 26 yr) had high-resolution neuroperfusion SPECT using both 99mTc-HMPAO and 99mTc-ECD on separate days.
RESULTS
Regional distribution of the two tracers differed. Technetium-99m-HMPAO accumulated more in the thalamus, frontal lobe, temporal lobe and cerebellum than 99mTc-ECD, which accumulated more in the occipital and parietal lobes. There was a considerable difference in the accumulation of the two tracers in the medial temporal lobe. The percent accumulations of 99mTc-HMPAO and 99mTc-ECD in the medial temporal lobe compared with the mean global cerebral cortical accumulation were 93.9% +/- 2.4% and 83.1% +/- 4.1% (mean +/- s.d.), respectively.
CONCLUSION
The results suggest that 99mTc-HMPAO and 99mTc-ECD require specific and separate criteria for diagnosing temporal lobe pathologies, such as dementia and temporal lobe epilepsy.
未标记
在正常大脑中比较了99m锝-六甲基丙烯胺肟（99mTc-HMPAO）和99m锝-半胱氨酸乙酯二聚体（99mTc-ECD）的区域分布。
方法
6名有偿健康志愿者（平均年龄26岁）在不同日期分别使用99mTc-HMPAO和99mTc-ECD进行高分辨率神经灌注单光子发射计算机断层扫描（SPECT）。
结果
两种示踪剂的区域分布不同。99m锝-HMPAO在丘脑、额叶、颞叶和小脑中的积聚比99mTc-ECD更多，而99mTc-ECD在枕叶和顶叶中的积聚更多。两种示踪剂在颞叶内侧的积聚存在显著差异。与全脑平均皮质积聚相比，99mTc-HMPAO和99mTc-ECD在颞叶内侧的积聚百分比分别为93.9%±2.4%和83.1%±4.1%（平均值±标准差）。
结论
结果表明，99mTc-HMPAO和99mTc-ECD在诊断颞叶病变（如痴呆和颞叶癫痫）时需要特定且不同的标准。
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