Geban O, Ertepinar H, Ozden S
Department of Science Education, Middle East Technical University, Ankara, Turkey.
Pharmazie. 1996 Jan;51(1):34-6.
A set of benzimidazole derivatives previously tested for their tuberculostatic activities was analyzed using the quantitative structure activity relationship (QSAR) method. The activity contributions for structural and substituent effects were determined from the correlation equations which were derived using stepwise regression technique. The resulting QSAR showed that the activity contributions of benzimidazoles depend on the size of the substituents at R2, the field effect of the substituents at R1 and structural parameter IY which indicates the presence of oxygen between the benzimidazole and benzyl or phenyl groups.
使用定量构效关系（QSAR）方法分析了一组先前测试过其抑菌活性的苯并咪唑衍生物。通过逐步回归技术推导的相关方程确定了结构和取代基效应的活性贡献。所得的QSAR表明，苯并咪唑的活性贡献取决于R2处取代基的大小、R1处取代基的场效应以及表示苯并咪唑与苄基或苯基之间存在氧的结构参数IY。
