氨基噻吩并嘧啶和噻吩并三唑并嘧啶衍生物作为潜在抗惊厥剂的合成
Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
作者信息
Santagati M, Modica M, Santagati A, Russo F, Spampinato S
机构信息
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
出版信息
Pharmazie. 1996 Jan;51(1):7-11.
PMID:8999439
Abstract
New aminothienopyrimidines and derivatives of the new thienotriazolopyrimidine ring system were synthesized to investigate their anticonvulsant activity. The tricyclic compounds 6a, c, e, f, m, o and p and two bicyclic derivatives 4f and 4o were tested. The pharmacological screening results are reported and discussed.
摘要
合成了新型氨基噻吩并嘧啶以及新型噻吩并三唑并嘧啶环系的衍生物，以研究它们的抗惊厥活性。对三环化合物6a、c、e、f、m、o和p以及两个双环衍生物4f和4o进行了测试。报告并讨论了药理筛选结果。
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