7-甲基-5-氧代-1,5-二氢-8-[1,2,4]-三唑并[4,3-c]嘧啶羧酸衍生物的合成与性质
Synthesis and properties of 7-methyl-5-oxo-1,5-dihydro-8-[1,2,4]-triazolo [4,3-c]pyrimidinecarboxylic acid derivatives.
作者信息
Długosz A, Machoń Z, Jasztold-Howorko R
机构信息
Department of Organic Chemistry, School of Medicine, Faculty of Pharmacy, Wrocław, Poland.
出版信息
Pharmazie. 1989 Sep;44(9):604-5.
PMID:2608705
Abstract
The synthesis of the new triazolo[4,3-c]pyrimidines is described, starting from derivatives of 5-carboxy-2-hydroxy-4-hydrazino-6-methylpyrimidine. The 4-methyl-2,3-dihydropyrazolo[3,4-d]pyrimidine-3,6-dione was also obtained. Some of triazolo[4,3-c]pyrimidines tested for biological activity were found inactive.
摘要
描述了从5-羧基-2-羟基-4-肼基-6-甲基嘧啶的衍生物开始合成新的三唑并[4,3-c]嘧啶。还得到了4-甲基-2,3-二氢吡唑并[3,4-d]嘧啶-3,6-二酮。对一些三唑并[4,3-c]嘧啶进行生物活性测试，发现它们没有活性。
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