Lambie D C, Caird F I
Age Ageing. 1977 Aug;6(3):133-7. doi: 10.1093/ageing/6.3.133.
Measurement of serum-phenytoin concentrations in 17 elderly patients showed that levels of 40 mumol/l or more were not produced by daily doses of less than 300 mg/day, but that doses of 350 mg/day or more produced higher and potentially toxic levels. Determination of mean values for Vmax and Km for phenytoin gave values little different from those for younger patients. The implications of these findings for anticonvulsant therapy in the elderly are discussed.
对17名老年患者血清苯妥英浓度的测量结果显示，每日剂量低于300毫克/天时，不会产生40微摩尔/升或更高的浓度，但每日剂量350毫克/天或更高时会产生更高且可能有毒的浓度。苯妥英的Vmax和Km平均值的测定结果与年轻患者的结果差异不大。本文讨论了这些发现对老年患者抗惊厥治疗的意义。
