老年人癫痫

Epilepsy in the elderly.

作者信息

Leppik I E

机构信息

MINCEP Epilepsy Care, 5775 Wayzata Boulevard, Suite 200, Minneapolis, MN 55416, USA.

出版信息

Curr Neurol Neurosci Rep. 2001 Jul;1(4):396-402. doi: 10.1007/s11910-001-0096-5.

DOI:10.1007/s11910-001-0096-5

PMID:11898548

Abstract

The active prevalence rate of epilepsy among persons over 65 years of age is approximately 1.5%, about twice the rate in younger adults. Treatment of epilepsy in the elderly is complicated by alterations in drug metabolism, use of concomitant medications, and multiple medical problems. Drug interactions are a major issue, and a full knowledge of the isoenzyme profile and protein-binding characteristics of each drug (antiepileptic and other) must be known.

摘要

65岁以上人群中癫痫的现患率约为1.5%，约为年轻人的两倍。老年人癫痫的治疗因药物代谢改变、合并用药以及多种医疗问题而变得复杂。药物相互作用是一个主要问题，必须全面了解每种药物（抗癫痫药物和其他药物）的同工酶谱和蛋白结合特性。