Zylberberg H, Carnot F, Mamzer M F, Blancho G, Legendre C, Pol S
Unité d'Hépatologie et Service de Transplantation Rénale, Hôpital Necker, Paris, France.
Transplantation. 1997 Jan 15;63(1):158-60. doi: 10.1097/00007890-199701150-00029.
Fibrosing cholestatic hepatitis is a well-described syndrome in patients with immunodeficiency and chronic hepatitis B. It is clinically, biologically, and histologically characterized by rapidly progressive hepatic failure, a mildly elevated serum aminotransferase level, an extensive periportal fibrosis associated with intense cholestasis, mild inflammatory cellular infiltrate, no cirrhosis, and a high hepatocellular level expression of B viral antigens. This syndrome reflected a direct hepatocytopathic injury linked to high intrahepatic viral antigen expression. Because the syndrome of fibrosing cholestatic hepatitis has not been described in chronic hepatitis C, we report the first well-characterized case in a renal transplant patient with chronic hepatitis C and discuss the clinical and pathogenic implications of such a syndrome in this setting.
纤维化淤胆型肝炎是免疫缺陷和慢性乙型肝炎患者中一种已被充分描述的综合征。其临床、生物学和组织学特征为快速进展的肝衰竭、血清氨基转移酶水平轻度升高、广泛的汇管区周围纤维化伴严重淤胆、轻度炎症细胞浸润、无肝硬化以及高水平的B病毒抗原肝细胞表达。该综合征反映了与高肝内病毒抗原表达相关的直接肝细胞病变性损伤。由于纤维化淤胆型肝炎综合征在慢性丙型肝炎中尚未见报道，我们报告了首例特征明确的慢性丙型肝炎肾移植患者病例，并讨论了该综合征在此情况下的临床和致病意义。
