尼日利亚人类免疫缺陷病毒和丙型肝炎病毒合并感染患者的部分生化及血液学异常情况

Selected biochemical and hematological abnormalities in Nigerians with human immunodeficiency virus and hepatitis C virus coinfection.

作者信息

Obienu Olive, Nwokediuko Sylvester

机构信息

Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria.

出版信息

Hepat Med. 2011 Jun 30;3:63-8. doi: 10.2147/HMER.S21735. eCollection 2011.

DOI:10.2147/HMER.S21735

PMID:24367222

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3846592/

Abstract

BACKGROUND

Liver disease has emerged as a major cause of morbidity and mortality in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, now that antiretroviral therapy has become more effective and has prolonged life expectancy in HIV-infected patients. The main objectives of this study were to determine the prevalence of HIV/HCV coinfection and the pattern of hematological and biochemical abnormalities associated with such dual infection.

METHODS

In this study, patients with HIV infection (cases) were tested for anti-HCV antibodies. There was a control group made up of apparently healthy individuals who came to hospital for medical examination for various reasons. They also had an anti-HCV antibody test. Those who tested positive for anti-HCV antibodies among the cases and control subjects were further evaluated for hemoglobin concentration, total white cell count, platelet count, and liver function.

RESULTS

One hundred and eighty HIV-infected patients and 180 control subjects participated in the study. The seroprevalence of anti-HCV antibodies in the HIV-infected patients and control subjects were 6.7% and 4.4%, respectively (P = 0.57). Serum total bilirubin, conjugated bilirubin, and alkaline phosphatase were significantly higher in the HIV/HCV coinfected patients compared with their HCV monoinfected counterparts (P = 0.0396, 0.0001, and 0.0016, respectively). The mean hemoglobin, white cell count, platelet count, and CD4+ T lymphocyte count were significantly lower in the HIV/HCV coinfected patients than the HCV monoinfected control group (P = 0.0082, 0.0133, 0.0031, and 0.0001, respectively).

CONCLUSION

The seroprevalence of anti-HCV antibodies in HIV-infected Nigerian patients is 6.7%. Patients with HIV/HCV coinfection have lower blood counts, higher serum bilirubin, and higher serum alkaline phosphatase compared with patients having HCV monoinfection.

摘要

背景

鉴于抗逆转录病毒疗法已变得更加有效且延长了艾滋病毒感染患者的预期寿命，肝病已成为人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）合并感染患者发病和死亡的主要原因。本研究的主要目的是确定HIV/HCV合并感染的患病率以及与这种双重感染相关的血液学和生化异常模式。

方法

在本研究中，对HIV感染患者（病例组）进行抗HCV抗体检测。有一个对照组，由因各种原因前来医院进行体检的表面健康个体组成。他们也进行了抗HCV抗体检测。病例组和对照组中抗HCV抗体检测呈阳性的患者进一步评估血红蛋白浓度、白细胞总数、血小板计数和肝功能。

结果

180例HIV感染患者和180名对照受试者参与了研究。HIV感染患者和对照受试者中抗HCV抗体的血清阳性率分别为6.7%和4.4%（P = 0.57）。与HCV单一感染的患者相比，HIV/HCV合并感染的患者血清总胆红素、结合胆红素和碱性磷酸酶显著更高（分别为P = 0.0396、0.0001和0.0016）。HIV/HCV合并感染的患者的平均血红蛋白、白细胞计数、血小板计数和CD4 + T淋巴细胞计数显著低于HCV单一感染的对照组（分别为P = 0.0082、0.0133、0.0031和0.0001）。