Chowdhury A R, Lorber S H
Am J Dig Dis. 1977 Sep;22(9):775-80. doi: 10.1007/BF01694507.
The effects of glucagon and secretin on food- or morphine-induced motor activity of the distal colon, rectum, and internal anal sphincter were investigated in 12 healthy subjects. Intraluminal pressure changes were measured using a triple-lumen polyvinyl tube assembly with 3 side orifices. Glucagon, administered intravenously, caused significant inhibition of food- or morphine-induced motor activity of both the distal colon and rectum. In contrast, secretin did not suppress morphine-induced motor activity but did significantly inhibit food-stimulated motor activity of the distal colon. The inhibitory effect of secretin on motor activity of the rectum was insignificant. Morphine, but not food, elevated the pressure of the anal sphincter which was not effected by glucagon or secretin. Hyperglycemia, produced by the infusion of 5% glucose, had no effect on motor activity. These studies demonstrate that glucagon but not secretin, in the doses employed, inhibits morphine-induced motor wave activity of both the distal colon and rectum and that this inhibitory effect is not secondary to hyperglycemia. Furthermore, the rise in anal sphincter pressure is not affected by glucagon or secretin.
在12名健康受试者中研究了胰高血糖素和促胰液素对食物或吗啡诱导的远端结肠、直肠和肛门内括约肌运动活性的影响。使用带有3个侧孔的三腔聚乙烯管组件测量腔内压力变化。静脉注射胰高血糖素可显著抑制食物或吗啡诱导的远端结肠和直肠的运动活性。相比之下，促胰液素并未抑制吗啡诱导的运动活性，但确实显著抑制了食物刺激的远端结肠运动活性。促胰液素对直肠运动活性的抑制作用不显著。吗啡而非食物可升高肛门括约肌压力，而胰高血糖素或促胰液素对此并无影响。输注5%葡萄糖产生的高血糖对运动活性没有影响。这些研究表明，在所使用的剂量下，胰高血糖素而非促胰液素可抑制吗啡诱导的远端结肠和直肠的运动波活性，且这种抑制作用并非继发于高血糖。此外，肛门括约肌压力的升高不受胰高血糖素或促胰液素的影响。
