Bengmark S, Böjesson B, Fredlund P E, Vang J O
Am J Surg. 1976 Sep;132(3):363-7. doi: 10.1016/0002-9610(76)90394-9.
Six patients with liver metastases from carcinoid or colon carcinoma underwent hepatic derterialization. This operation, known to cause both tumor necrosis and liver cell damage, caused considerable increases of several lysosomal acid hydrolases in the circulation. Thus, beta-glucosidase showed a small temporary increase during the operation, followed by a slower but higher reaction reaching a maximum 12 to 36 hours postoperatively. Similar reactions were noted for beta-glucuronidase, acid phosphatase, beta-galactosidase, arylsuphatase A, and N-acetyl-beta-glucosaminidase while no reactions were found for cathepsin D. Very high enzyme levels occurred in a patient dying from bleeding complications in the postoperative period.
6例患有类癌或结肠癌肝转移的患者接受了肝动脉阻断术。已知该手术会导致肿瘤坏死和肝细胞损伤，还会使循环中几种溶酶体酸性水解酶显著增加。因此，β-葡萄糖苷酶在手术期间出现了短暂的小幅升高，随后反应较慢但升高幅度更大，在术后12至36小时达到峰值。β-葡萄糖醛酸酶、酸性磷酸酶、β-半乳糖苷酶、芳基硫酸酯酶A和N-乙酰-β-葡萄糖胺酶也出现了类似反应，而组织蛋白酶D未出现反应。在术后因出血并发症死亡的一名患者中出现了极高的酶水平。
