Woolf C M, Gianas A D
Am J Hum Genet. 1977 Sep;29(5):503-7.
Fluctuating asymmetry was studied in cleft lip propositi and their normal sibs and parents. The traits examined were a-b ridge counts and fingerprint patterns. Propositi with a family history of this congenital malformation and their normal sibs and parents were significantly different from the controls for this type of asymmetry. Propositi without a family history and their normal sibs and parents were similar to the controls. These results support the hypothesis that familial and sporadic cases of congenital cleft lip are different entities and give evidence for a genetic mechanism in the parents and sibs of the familial cases that may account for this congenital disorder and, concomitantly, increased fluctuating asymmetry.
对唇裂患者及其正常的同胞和父母进行了波动不对称性研究。所检查的特征为a - b嵴计数和指纹图案。有这种先天性畸形家族史的患者及其正常的同胞和父母在这种不对称类型上与对照组有显著差异。无家族史的患者及其正常的同胞和父母与对照组相似。这些结果支持了以下假说：先天性唇裂的家族性病例和散发性病例是不同的实体，并为家族性病例的父母和同胞中存在一种遗传机制提供了证据，这种遗传机制可能导致这种先天性疾病，同时也导致波动不对称性增加。
