Finland M, Barnes M W
Am J Med Sci. 1977 Jul-Aug;274(1):4-12. doi: 10.1097/00000441-197707000-00001.
An analysis is presented of the duration of hospitalization of the patients with acute bacterial (purulent) meningitis which occurred at Boston City Hospital during 12 selected years between 1935 and 1972. Considerable differences in the length of stay in the hospital were noted depending on the bacterial etiology, whether the infection was present on admission or acquired within the hospital, and, of course, whether the patient survived or died. Most of the deaths occurred within the first few days after admission or after the diagnosis was first established, but even among fatal cases, the survival time differed depending on the etiology and site of acquisition of the infection. During the years after effective antibiotics became available the hospital stay of patients who survived after admission for meningococcal, influenzal, or pneumococcal meningitis was shorter than before. The same has not been true for meningitis caused by other gram-positive cocci, gram-negative rods, or mixed infections, probably reflecting the relative ineffectiveness of antimicrobial therapy in such patients.
本文对1935年至1972年期间12个选定年份在波士顿市医院发生的急性细菌性(化脓性)脑膜炎患者的住院时长进行了分析。根据细菌病因、入院时是否存在感染或在医院内获得感染,当然还有患者存活或死亡情况,发现住院时长存在显著差异。大多数死亡发生在入院后的头几天或首次确诊后,但即使在致命病例中,存活时间也因感染的病因和感染获得部位而异。在有效抗生素问世后的几年里,因脑膜炎球菌性、流感性或肺炎球菌性脑膜炎入院后存活的患者住院时间比以前短。但对于由其他革兰氏阳性球菌、革兰氏阴性杆菌或混合感染引起的脑膜炎患者,情况并非如此,这可能反映了抗菌治疗对此类患者的相对无效性。