通过气相色谱-质谱联用技术鉴定大鼠体内的吡咯戊酮代谢物，并采用气相色谱-氮磷检测法测定吡咯戊酮。
Identification of a pyrovalerone metabolite in the rat by gas chromatography-mass spectrometry and determination of pyrovalerone by gas chromatography-nitrogen-phosphorus detection.
作者信息
Lho D S, Lee J, Kim S, Park J, Shin H S
机构信息
Doping Control Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
出版信息
J Chromatogr B Biomed Appl. 1996 Dec 6;687(1):253-9. doi: 10.1016/s0378-4347(96)00183-1.
Pyrovalerone and its hydroxylated metabolite have been identified by gas chromatography-mass spectrometry in rat urine and plasma. A sensitive gas chromatographic method for the quantitative analysis of pyrovalerone in rat urine and plasma is described. The method also permits the quantitative monitoring of the urinary excretion of the drug and its metabolite. Pyrovalerone and its hydroxylated metabolite are detected up to 18 h after a single oral administration to the rat at a dose of 20 mg/kg.
已通过气相色谱-质谱法在大鼠尿液和血浆中鉴定出吡咯戊酮及其羟基化代谢物。本文描述了一种用于定量分析大鼠尿液和血浆中吡咯戊酮的灵敏气相色谱方法。该方法还可对药物及其代谢物的尿排泄进行定量监测。给大鼠单次口服20mg/kg剂量的吡咯戊酮后，在长达18小时内均可检测到吡咯戊酮及其羟基化代谢物。
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