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具有线性四聚乳糖胺链和三个乳糖胺分支的核心2类O-聚糖的立体控制合成。

Stereocontrolled syntheses of O-glycans of core class 2 with a linear tetrameric lactosamine chain and with three lactosamine branches.

作者信息

Wang Z G, Zhang X F, Ito Y, Nakahara Y, Ogawa T

机构信息

Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.

出版信息

Carbohydr Res. 1996 Dec 13;295:25-39. doi: 10.1016/s0008-6215(96)90116-0.

DOI:10.1016/s0008-6215(96)90116-0
PMID:9002183
Abstract

Synthetic routes to O-glycans of core class 2 with a linearly extended tetralactosamine moiety and with three lactosamine branches are discussed. By a glycosyl fluoride-method, the mono- and the di-lactosaminyl units were attached to the core disaccharide (Gal beta 1-->3GalN3) derivatives in high stereoselectivity.

摘要

讨论了具有线性延伸的四乳糖胺部分和三个乳糖胺分支的核心2类O-聚糖的合成路线。通过糖基氟化物方法，单乳糖胺基和二乳糖胺基单元以高立体选择性连接到核心二糖（Galβ1→3GalN3）衍生物上。

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