Abel J, Spannbrucker N, Fandrey J, Jelkmann W
Department of Internal Medicine, University of Bonn, Germany.
Eur J Haematol. 1996 Nov;57(5):359-63. doi: 10.1111/j.1600-0609.1996.tb01393.x.
The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor alpha, interleukin-1 beta and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.
免疫系统在促红细胞生成素产生控制中的作用仍未得到充分了解。在此，对10名脓毒症患者在入住内科重症监护病房后的长达4天内，测定了循环免疫反应性促红细胞生成素、肿瘤坏死因子α、白细胞介素-1β和白细胞介素-6的水平。数据表明，尽管促炎细胞因子水平升高，但促红细胞生成素的产生并未受到抑制。在6名未存活的患者中，循环促红细胞生成素和白细胞介素-6大幅增加。未存活者血清促红细胞生成素水平的模式类似于急性期蛋白，且与血红蛋白浓度无关。与白细胞介素-6相似，血清促红细胞生成素水平异常升高似乎是脓毒症休克患者的不良预后指标。
