Xing W, Na R
Department of Biology, Inner Mongolia Medical College, Hohhote, China.
Mutat Res. 1996 Nov 11;372(1):75-8. doi: 10.1016/S0027-5107(96)00168-6.
The effects of 21 amino acids on sister-chromatid exchanges (SCEs) in human lymphocytes were investigated. Addition of each of the 21 amino acids, originally in a composition of the culture medium RPMI 1640, at three different concentrations (10 micrograms/ml, 50 micrograms/ml and 100 micrograms/ml) caused a dose-independent increase in SCE frequency. The results indicated that amino acids, although indispensable for cells in vivo and in vitro, may be SCE-inducing agents.
研究了21种氨基酸对人淋巴细胞姐妹染色单体交换（SCE）的影响。在三种不同浓度（10微克/毫升、50微克/毫升和100微克/毫升）下，将最初存在于培养基RPMI 1640中的21种氨基酸逐一添加，导致SCE频率呈剂量非依赖性增加。结果表明，氨基酸虽然在体内和体外对细胞都是必不可少的，但可能是SCE诱导剂。
