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Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures.

作者信息

Egeli U

机构信息

Department of Medical Biology, Faculty of Medicine, University of Uludag, Bursa, Turkey.

出版信息

Teratog Carcinog Mutagen. 1998;18(4):163-9.

PMID:9804272
Abstract

This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.

摘要

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