Mossey P A, McColl J H, Stirrups D R
Department of Dental Health, University of Dundee, Scotland.
Cleft Palate Craniofac J. 1997 Jan;34(1):27-35. doi: 10.1597/1545-1569_1997_034_0027_dbclwo_2.3.co_2.
The purpose of this study was to identify and compare lateral cephalometric measurements in noncleft parents of children with cleft palate (CP) and cleft lip (CL), and cleft lip and palate (CLP). The hypothesis was that discriminant analysis would enable identification of morphometric features that predispose to orofacial clefting and that differ for CP, CL, and CLP and are unevenly distributed within parental pairs.
This was a prospective, parametric analysis.
The study was conducted by the Department of Dental Health, University of Dundee, and the Department of Statistics, University of Glasgow, Scotland.
From a completely ascertained sample of 286 children with cleft lip and/or palate born in the West of Scotland between January 1, 1980, and December 31, 1984, a sample of 83 parents of children with non-syndromic clefts volunteered for lateral cephalometric examination.
Thirty-seven cranial and 99 facial landmarks were identified and 37 linear, angular, and area parameters were used to describe the craniofacial skeleton. Analysis of variance was used for a three-way comparison of CL/CLP/CP, and stepwise discriminant analysis was used to determine which variables discriminate best between cleft lip with or without cleft palate [CL(P)] and isolated cleft palate (CP) parents.
There were no significant differences whatsoever in the craniofacial morphology between the parents of children with CL and CLP, but differences were found between the CL(P) and CP groups. The most significant of these were in mandibular length, ramus length, mandibular area, and cranial area. Mandibular ramus length alone discriminated between the two groups in 71.4% of CP and in 62.5% of CL(P) cases, while separate analysis of fathers and mothers showed that ramus length and cranial height together reliably distinguish between mothers in 75% of CP and 80% of CL(P) cases.
Previous studies suggests that unaffected parents with non-syndromic children with cleft lip and/or palate have differences in their craniofacial morphology when compared to the general population. This study indicates that these morphologic features differ for CP and CL(P).
本研究旨在识别并比较腭裂（CP）、唇裂（CL）及唇腭裂（CLP）患儿非患裂父母的头颅侧位测量值。研究假设为判别分析能够识别出易导致口面部裂隙的形态学特征，这些特征在CP、CL和CLP之间存在差异，且在父母双方中分布不均。
这是一项前瞻性参数分析。
该研究由邓迪大学牙科健康系和苏格兰格拉斯哥大学统计系开展。
从1980年1月1日至1984年12月31日在苏格兰西部出生的286例唇裂和/或腭裂患儿的完全确诊样本中，抽取83例非综合征性腭裂患儿的父母作为志愿者进行头颅侧位检查。
确定了37个颅骨标志点和99个面部标志点，并使用37个线性、角度和面积参数来描述颅面骨骼。采用方差分析对CL/CLP/CP进行三向比较，并使用逐步判别分析来确定哪些变量能最佳地区分有或无腭裂的唇裂[CL(P)]患儿父母和孤立性腭裂（CP）患儿父母。
CL和CLP患儿父母的颅面形态无显著差异，但CL(P)组和CP组之间存在差异。其中最显著的差异在于下颌长度、升支长度、下颌面积和颅骨面积。仅下颌升支长度就能在71.4%的CP病例和62.5%的CL(P)病例中区分两组，而对父亲和母亲分别进行分析显示，升支长度和颅骨高度共同能在75%的CP病例和80%的CL(P)病例中可靠地区分母亲。
先前的研究表明，与普通人群相比，非综合征性唇裂和/或腭裂患儿的未患病父母颅面形态存在差异。本研究表明，这些形态学特征在CP和CL(P)之间存在差异。
