99mTcN核心对L,L-EC和L,L-ECD的99mTc配合物生物及物理化学行为的影响
Influence of a 99mTcN core on the biological and physicochemical behavior of 99mTc complexes of L,L-EC and L,L-ECD.
作者信息
Mang'era K O, Vanbilloen H P, Bellande E, Pasqualini R, Verbruggen A M
机构信息
Laboratory of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, K. U. Leuven, U.Z. Gasthuisberg, Belgium.
出版信息
Nucl Med Biol. 1996 Nov;23(8):987-93. doi: 10.1016/s0969-8051(96)00150-3.
99mTc-nitrido complexes of L,L-ethylene dicysteine (99mTcN-L,L-EC) and 99mTcN-L,L-ethylene dicysteine diethylester (99mTcN-L,L-ECD) were prepared and their characteristics compared to those of the respective 99mTc-oxo complexes. 99mTcN-L,L-EC and 99mTcO-L,L-EC migrate to similar extents during electrophoresis at pH 12, but, at pH6, 99mTcN-L,L-EC migrates further than 99mTcO-L,L-EC. Renal excretion of 99mTcN-L,L-EC is inferior to that of 99mTcO-L,L-EC, indicating that the TcN-glycine sequence has lower affinity for the renal tubular system. Both 99mTcO-L,L-ECD and 99mTcN-L,L-ECD are neutral, but 99mTcN-L,L-ECD is hydrophilic and shows minimal brain uptake in both mice and the baboon.
制备了L,L-乙二胺四乙酸（99mTcN-L,L-EC）和99mTcN-L,L-乙二胺四乙酸二乙酯（99mTcN-L,L-ECD）的99mTc-氮化物配合物，并将它们的特性与相应的99mTc-氧代配合物的特性进行了比较。99mTcN-L,L-EC和99mTcO-L,L-EC在pH 12的电泳过程中迁移程度相似，但在pH 6时，99mTcN-L,L-EC比99mTcO-L,L-EC迁移得更远。99mTcN-L,L-EC的肾脏排泄比99mTcO-L,L-EC差，这表明TcN-甘氨酸序列对肾小管系统的亲和力较低。99mTcO-L,L-ECD和99mTcN-L,L-ECD都是中性的，但99mTcN-L,L-ECD是亲水性的，在小鼠和狒狒中脑摄取都极低。
Zotero 插件